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Characterization of the in Vitro Effects of Glucocorticosteroids on NK Cell Activity
Author(s) -
Pedersen B. K.,
Beyer J. M.
Publication year - 1986
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1986.tb00303.x
Subject(s) - percoll , effector , peripheral blood mononuclear cell , cell , in vitro , cell adhesion , chemistry , monocyte , microbiology and biotechnology , biology , immunology , biochemistry
The NK cell activity of mononuclear cells as well as monocyte‐depleted, Percoll‐fractionated, NK cell‐enriched effector cells against K 562 target cells was inhibited by methylprednisolone (MP) and hydrocortisone (HC) in a dose‐dependent manner. The effector/target cell conjugate formation was studied in a single cell agarose assay, and it was shown that MP and HC partly inhibited the NK cell activity by inhibition of the adhesion of effector cells to target.