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A Double‐Blind, Multicenter Immunotherapy Trial in Children, Using a Purified and Standardized Cladosporium herbarum Preparation II. In Vitro Results
Author(s) -
Karlsson R.,
Agrell B.,
Dreborg S.,
Foucard T.,
Kjellman N.I. M.,
Koivikko A.,
Einarsson R.
Publication year - 1986
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1986.tb00290.x
Subject(s) - cladosporium , immunoglobulin e , immunology , medicine , allergen , immunotherapy , radioallergosorbent test , histamine , placebo , antibody , allergy , asthma , double blind , biology , microbiology and biotechnology , pathology , immune system , aspergillus , alternative medicine
This double‐blind immunotherapy trial in children, using a purified and standardized Cladosporium herbarum allergen preparation, has shown that children with mould asthma and/or rhinoconjunctivitis, responded to immunotherapy with a decrease in specific IgE and a significant increase in specific IgG. There was a marked increase in tile ratio specific IgG/specific IgE, as a result of active treatment. IgE‐CRIE radiostaining patterns showed no pronounced changes after 10 months' active treatment and no “new sensitivities” could be detected in the studied patients, IgG‐CRIE radiostaining, primarily directed towards the important allergens, was significantly increased in the active group and particularly towards Ag‐12 (partially identical to a previously described major allergen in Cladosporium herbarum. Ag‐54). Children treated with histamine placebo showed no change antibody patterns during 10 months of treatment.