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Influence of Bacterial Endotoxins on Basophil Histamine Release Potentiation of Antigen‐ and Bacteria‐Induced Histamine Release
Author(s) -
Norn S.,
Bæk L.,
Jensen C.,
Skov P. Stahl,
Permin H.,
Jarløv J. O.,
Koch C.
Publication year - 1986
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1986.tb00288.x
Subject(s) - histamine , bacteria , basophil , microbiology and biotechnology , immunoglobulin e , immunology , long term potentiation , antigen , chemistry , histamine h4 receptor , biology , pharmacology , histamine h2 receptor , antibody , biochemistry , receptor , antagonist , genetics
The histamine‐releasing capability of lipopolysaccharides (LPS) was examined in human leukocyte suspensions. LPS alone did not release histamine, but was found to enhance the histamine release caused by anti‐IgE. Also the IgE‐mediated histamine release caused by specific antigens (allergens or bacteria) in sensitized individuals was enhanced by LPS. The potentiating effect of LPS was observed in grass pollen and dog dander allergic patients as well as in patients sensitized to E. coli or Staph, aureus bacteria. No potentiation was obtained by exposure to unspecific allergens or bacteria to which the persons were not sensitized. Bacteria can release histamine by immunological or nonimmunological mechanisms, and only the immunological histamine release was found to be potentiated by LPS. It is speculated that endotoxins reinforce release of histamine caused by allergens in allergic patients or by bacteria in persons sensitized to these microorganisms.