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IgG and IgE Antibody Patterns after Immunotherapy with Monomethoxy Polyethyleneglycol Modified Honey Bee Venom
Author(s) -
Nordvall S. L.,
Uhlin T.,
ÖHman S.,
Björkander J.,
Malling H.J.,
Wheke B.,
Dreborg S.,
Lanner Å.,
Einarsson R.
Publication year - 1986
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1986.tb00283.x
Subject(s) - immunogenicity , immunoglobulin e , antibody , immunology , venom , immunotherapy , radioallergosorbent test , hyaluronidase , allergen , medicine , immunoelectrophoresis , antigen , allergy , chemistry , immune system , enzyme , biochemistry
Antibody responses to honey bee venom (HBV) were studied in 13 patients during a 4‐month course of immunotherapy with monomethoxy polyethyleneglycol (mPEG) modified venom. There was a rise of HBV‐specific IgG antibodies as measured by IgG‐RAST in all patients and a slight decrease of IgE antibody in most of them. The IgG‐antibody responses during mPEG‐HBV treatment as examined by crossed radio‐immunoelectrophoresis were directed to phospholipase A, hyaluronidase, acid phosphatase and to another allergen, antigen 1. Thus, despite a high degree of mPEG‐ modification of HBV, the immunogenicity of the most important HBV allergens was retained.