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A Preliminary Study of Immunotherapy with a Monomethoxy Polyethylene Glycol Modified Honey Bee Venom Preparation
Author(s) -
ÖHman S.,
Björkandkr J.,
Dreborg S.,
Lanner Å.,
Malling H.J.,
Weeke B.
Publication year - 1986
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1986.tb00282.x
Subject(s) - venom , medicine , immunotherapy , polyethylene glycol , allergy , immunoglobulin e , radioallergosorbent test , sting , bee venom , immunology , pharmacology , dermatology , allergen , antibody , biology , immune system , biochemistry , zoology , engineering , aerospace engineering
Monomethoxy polyethylene glycol (mPEG) modified honey bee venom (HBV) immunotherapy (IT) has been studied in 14 patients allergic to honey bee venom. Doses could be increased more rapidly and higher doses were reached compared to regular venom immunotherapy. No general side effects were seen, although large local swellings found somewhat more often than with regular HBV. Most patients could easily be switched from the modified to the unmodified venom. Eight patients experienced and tolerated field stings. Skin testing showed a decreased allergenicity of the mPEG‐HBV. The mean HBV‐specific IgE level was below pretreatment level already after only weeks of IT. The HBV‐specific IgG response was very good.