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Histopathological Support of Antagonism of Allergen‐Induced Mast Cell Mediator Release in Human Skin by a Beta 2 ‐Agonist
Author(s) -
Gronnkberg R.,
Lagerholm B.
Publication year - 1986
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1986.tb00278.x
Subject(s) - terbutaline , allergen , mast cell , agonist , immunology , medicine , allergy , pharmacology , chemistry , asthma , receptor
The site of antagonistic action on allergen‐induced early skin reactions by the beta 2 ‐agonist terbutaline was studied by light microscopy in 10 atopic subjects. Pretreatment with 1 μg terbutaline intradermally 5 min prior to challenge with horse dander allergen produced an approximate inhibition of 85 and 55% of flare and wheal responses respectively ( P < 0.001) Biopsy specimens obtained from skin sites injected with allergen alone showed a reduced number of remaining stainable mast cells as compared to sites injected with terbutaline prior to allergen ( P < 0.05, Sign test). The data support the concept of in viva inhibition of the mast cell mediator release reaction in atopic skin by terbutaline.