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Inhibitory Effect of N‐(3′, 4′‐dimethoxycinnamoyl) Anthranilic Acid (N‐5′) on SRS‐A Mediated Bronchoconstriction in the Guinea Pig in Vivo
Author(s) -
Fujimura M.,
Koshino T.,
Ishizaki T.,
Minami S.,
Saga T.,
Miyabo S.
Publication year - 1985
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1985.tb02667.x
Subject(s) - bronchoconstriction , inhalation , guinea pig , pharmacology , in vivo , anthranilic acid , chemistry , medicine , leukotriene c4 , anaphylaxis , asthma , immunology , leukotriene , allergy , anesthesia , biochemistry , biology , microbiology and biotechnology
Slow‐reacting substance of anaphylaxis (SRS‐A) is an important factor mediating bronchoconstriction in asthma. We developed a guinea pig model for SRS‐A‐mediated bronchoconstriction induced by antigen inhalation. Using this model, we investigated the effect of N‐(3′, 4′‐dimethoxycinnamoyl) anthranilic acid (N‐5′), a new anti‐allergic drug, on the bronchoconstriction. FPL 55712 inhibited most of the bronchoconstriction induced by antigen inhalation. N‐5′inhibited the antigen‐induced bronchoconstriction in a dose‐dependent fashion. Intraperitoneal administration of 200 mg/kg N‐5′was effective for 40 min after antigen inhalation, while the effect of 60 mg/kg lasted only 7 min. On the other hand, 200 mg/kg N‐5′showed no inhibitory effect on the bronchoconstriction caused by direct inhalation of leukotriene C 4 , a component of SRS‐A. These findings indicate that one of the anti‐allergic actions of N‐5′is due to inhibition of synthesis and/or release of SRS‐A.