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Non‐Hereditary Angioedema Treated with Tranexamic Acid
Author(s) -
Munch E. P.,
Weeke B.
Publication year - 1985
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1985.tb02666.x
Subject(s) - tranexamic acid , medicine , itching , angioedema , anesthesia , placebo , hereditary angioedema , surgery , dermatology , blood loss , alternative medicine , pathology
Ten patients with frequent attacks of non‐hereditary angioedema were treated with tranexamic acid or placebo in a double blind manner, each period lasting 3 months. During the tranexamic acid period nine patients became symptom‐free, or substantially improved, while one was unaffected ( P < 0.05). In four patients itching was a major accompanying complaint which was relieved in three. Diarrhoea and abdominal discomfort were more pronounced during tranexamic acid treatment ( P < 0.05), but only necessitated dose reduction in one patient. Four years later contact was obtained with eight of the nine responders and six were still taking tranexamic acid regularly, while in two patients the attacks were so infrequent that the drug was not taken regularly.