Premium
Bronchial Histamine Challenge
Author(s) -
Pavlovic M.,
HolsteinRathlou N.H.,
Madsen F.,
Svendsen U. Gerner,
Weeke B.
Publication year - 1985
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1985.tb00885.x
Subject(s) - histamine , correlation coefficient , reproducibility , basal (medicine) , medicine , airway resistance , asthma , chemistry , anesthesia , mathematics , chromatography , statistics , insulin
We compared the provocative concentration (PC) values obtained by two different methods of performing bronchial histamine challenge. One test was done on an APTA, an apparatus which allows simultaneous provocation with histamine and measurement of airway resistance (R tot ) by the interrupter method. The second test was a conventional tidal breathing method, with measurement of the FEV 1 . There was a high correlation between the PC 20 ‐FEV 1 and the PC 30 ‐, PC 40 ‐ and PC 50 ‐R tot values. The correlation coefficients were 0.85, 0.71 and 0.70 ( P < 0.05) respectively. We further tested the reproducibility of the histamine challenge done on the APTA. When the PC 30 ‐R tot values were compared, a correlation coefficient of 0.56 (NS) was found. For the PC 40 ‐ and PC 50 ‐R tot values the correlation coefficients were 0.65 ( P < 0.05) and 0.70 ( P < 0.02) respectively. We conclude that the APTA is useful for routine bronchial histamine challenge when 40–50% increase in basal R tot is used as endpoint.