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Failure of Verapamil in Inhibiting Allergen‐Induced Histamine Release in Vivo
Author(s) -
Ting S.,
Mansfield L. E.,
Raults D. O.
Publication year - 1985
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1985.tb00260.x
Subject(s) - verapamil , histamine , ragweed , in vivo , pharmacology , medicine , allergy , allergen , immunology , calcium , biology , microbiology and biotechnology
In order to evaluate the effect of Verapamil on human cutaneous anaphylactic responses, ragweed‐sensitive individuals were skin tested with ragweed, ragweed plus Verapamil, and Verapamil alone. In addition, using a skin chamber technique, the effect of Verapamil on antigen‐induced histamine release in vivo was investigated. The results suggest that Verapamil, applied locally in non‐irritant doses, does not affect Type I hypersensitivity skin reactions.