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Effect of Betamethasone on the Dual Reaction to Anti‐Human IgE in Man: Influence of Time Interval between Administration of Drug and Anti‐IgE
Author(s) -
Gröunneberg R.,
Strandberg K.
Publication year - 1985
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1985.tb00224.x
Subject(s) - betamethasone , immunoglobulin e , histamine , medicine , pharmacology , immunology , antibody
The influence of the time interval between administration of a glucocorticoid, betamethasone, and anti‐IgE on the effect of the drug on the early and late phase response (LPR) to anti‐IgE was examined in 38 volunteers in a randomized controlled study. The immediate flare and wheal responses to intradermally (i.d.) injected anti‐IgE were inhibited by approximately 20 and 30% respectively by a 10 day i.d. pretreatment period with repeated 50 μg doses (total 300 μg) of betamethasone ( P < 0.01), whereas responses to histamine were not influenced. A single i.d. injection of 50 μg betamethasone 24 h prior to anti‐IgE challenge attenuated the wheal response ( P < 0.05), whereas injection of the drug 2 h prior to and together with anti‐IgE had no influence on the early response. Corresponding LPRs were reduced approximately 30% throughout the observation period of 1–24 h ( P < 0.01). Injecting the drug i.d. 30 min following anti‐IgE challenge had no significant influence on the total observation period (1–24 h) of the LPR but antagonized the LPR by 35% at 6–24 h ( P < 0.01). It is concluded that glucocorticoids inhibit IgE‐dependent LPRs. When extending the topical pretreatment period with the compounds also the early part of the allergic reaction is attenuated.