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A Pharmacokinetic Study of the Recommended Dosing Schedules of Theo‐Dur and Uniphylline
Author(s) -
Purkiss R.,
Cope A.,
Edwards C.
Publication year - 1984
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1984.tb01985.x
Subject(s) - pharmacokinetics , theophylline , dosing , medicine , pharmacology
Theo‐Dur, 300 mg twice daily, and Uniphylline, 600 mg once daily taken with food were compared in an open cross‐over study in healthy volunteers. Uniphylline had significantly ( P < 0.001) higher peaks, lower troughs and wider variation in theophylline concentrations than Theo‐Dur. Peak plasma concentrations were reached earlier for Theo‐Dur but the difference failed to reach statistical significance (0.05 < P < 0.1). There was no significant difference between the two drugs in area under the plasma concentration time curve. Therapeutic occupancy lasted significantly longer ( P < 0.05) with Theo‐Dur; eight volunteers attained 24 h therapeutic occupancy after administration of Theo‐Dur compared to 4 h with Uniphylline.