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Sustained Inhibition of Antigen‐Induced Histamine Release from Human Lung by the β 2 ‐Adrenoceptor Agonist Terbutaline
Author(s) -
Petersson BengtÅke
Publication year - 1984
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1984.tb01952.x
Subject(s) - terbutaline , histamine , agonist , chemistry , antigen , pharmacology , lung , endocrinology , medicine , asthma , immunology , receptor
Antigen‐induced histamine release from passively sensitized human lung tissue was inhibited in the presence of the β 2 ‐adrenoceptor agonist, terbutaline. A sustained and statistically significant suppression was detected in the concentration interval 3 × 10 −8 ‐1 × 10 −6 M. Fifty per cent inhibition IC 50 , was obtained at an interpolated concentration of 5.3 × 10 −8 ± 0.4 × 10 −8 M ( n = 13), when the histamine secretion was elicited with optimum concentration of antigen. Histamine release induced with a suboptimum concentration of antigen was inhibited to a greater extent than release initiated with optimum concentration. The data in the present investigation support the concept that terbutaline‐induced inhibition of mediator release from human lung tissue can contribute to the clinical effectiveness of the drug during treatment of allergic asthma.