Premium
Effect of Platelet Activating Factor on the Human Nasal Mucosa
Author(s) -
Pipkorn Ulf,
Karlsson Göran,
Bake Björn
Publication year - 1984
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1984.tb01946.x
Subject(s) - nostril , rhinomanometry , vasoconstriction , platelet activating factor , mucous membrane of nose , nose , medicine , platelet , blood flow , blood vessel , anesthesia , immunology , pharmacology , anatomy
In order to determine the effect of PAF‐acether on the vascular bed in the human nose, 11 healthy volunteers were studied. Rhinomanometry was performed to determine the effect on the capacitance vessels, and the 133 Xe wash‐out method enabled determination of the mucosal blood flow, regulated mainly by the resistance vessels. These measurements were made before and after topical administration of PAF‐acether in three different doses; 0.26 μg 2.6 μg and 26 μg per nostril. The results indicate that PAF‐acether induces a dose‐dependent vasoconstriction of the capacitance vessels and a reduction in mucosal blood flow. That PAF‐acether should be a principal mediator in the allergic reaction in the human nose is not supported by these findings.