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Suppression of Immediate and Late Anti‐IgE‐Induced Skin Reactions by Topically Applied Alcohol/Onion Extract
Author(s) -
Dorsch Walter,
Ring Johannes
Publication year - 1984
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1984.tb01932.x
Subject(s) - ethanol , immunoglobulin e , alcohol , chemistry , medicine , skin reaction , pharmacology , antibody , immunology , biochemistry
In a double blind study, alcohol/onion extract (5% ethanol) was injected simultaneously with 20 IU and 200 IU rabbit anti‐human‐IgE intradermally in 12 adult volunteers (6 atopics, 6 non‐atopics). Diameters of wheals and flares were measured 10 mm after and compared with control sites challenged with 20 IL1 and 200 IL1 anti‐IgE in a 5% ethanol solution. The skin sites were then treated epidermally with 45% alcohol/onion extract and 45% ethanol under occlusion. Diameters of late cutaneous reactions were measured hourly. Oedema formation was clinically estimated according to an arbitrary scale and skin thickness measured with a calliper. In the onion‐treated skin sites the wheal areas were significantly reduced (20 IU: control: 108 ± 53 mm 2 : onion 69 ± 42 mm 2 , P < 0.05;, 200 IL anti‐lgE: control: 152 ±, 25 mm 2 , onion: 138 ±, 26 mm 2 , P < 0.02). The oedema formation during the late phase skin reaction was markedh depressed (P < 0.005 at 2 h, P < 0.01 at 4 and 6 h, P < 0.02 at 8 h). The extent of late skin reactions was slightly, but not significantly reduced. Obviously. onions contain pharmacologically active substances with anti‐inflammatory and or allergic properties.