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Lymphocyte Subpopulations in Patients with Allergic Rhinitis
Author(s) -
Kus J.,
Tse K. S.,
Enarson D.,
Grzybowski S.,
ChanYeung M.
Publication year - 1984
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1984.tb00871.x
Subject(s) - cytotoxic t cell , immunology , suppressor , immunotherapy , monoclonal antibody , medicine , antibody , inducer , t lymphocyte , lymphocyte , immune system , t cell , biology , cancer , in vitro , biochemistry , gene
The lymphocyte subpopulations were classified using monoclonal antibodies specific for B lymphocytes (B1 antibodies), T lymphocytes (T11 and OKT3 antibodies). Helper/inducer T cells (T4 antibodies) and suppressor/cytotoxic T cells (T8 antibodies). Three groups of subjects were studied: 20 normal controls, 29 patients with allergic rhinitis and a subgroup of nine patients who had received immunotherapy. The proportion of B Lymphocytes, total T cells and T4 positive (helper/inducer) cells were not significantly different between the groups, but allergic patients were found to have a decreased proportion of suppressor T8 positive (suppressor/cytotoxic) cells and hence a high helper/suppressor cell ratio. These received immunotherapy. These results imply that a suppressor cell deficiency may be an underlying mechanism of allergic disease, and that immunotherapy could correct the suppressor cell deficiency.