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Astemizole in the Treatment of Hay Fever
Author(s) -
Malmberg H.,
Holopainen E.,
Grahne B.,
Binder E.,
Savolainen S.,
Sundberg S.
Publication year - 1983
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1983.tb01615.x
Subject(s) - hay fever , astemizole , medicine , dermatology , allergy , immunology , anesthesia
A double‐blind parallel trial of astemizole, pheniramine and placebo was carried out in 15 patients with hay fever. Astemizole is a new potent H 1 ‐antihistamine with long duration of action but devoid of central activity. Evaluation criteria were daily symptom‐ and side effect score cards, daily nasal peak flow measurements, clinical examination and blood tests. Control of nasal symptoms was significantly better with both antihistamines than with placebo. Tiredness and anticholinergic side effects were less common in the astemizole group than in the pheniramine group. No significant changes in the “safety evaluation” blood tests were observed.