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Effect of Cimetidine on Exogenous Histamine Inhibition of Histamine Release in Vivo
Author(s) -
Ting Stanislaus,
Zweiman Burton,
Lavker Robert M.,
Dunsky Eliot H.
Publication year - 1983
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1983.tb00850.x
Subject(s) - histamine , cimetidine , in vivo , histamine h2 receptor , eosinophil , histamine h4 receptor , histamine h1 receptor , pharmacology , histamine receptor , chemistry , antagonist , mast cell , histamine n methyltransferase , ragweed , receptor , medicine , endocrinology , allergy , immunology , biology , biochemistry , asthma , microbiology and biotechnology
We previously reported that exogenous histamine inhibits in vivo histamine release and eosinophil accmulation in ragweed‐challenged skin sites of sensitive human subjectes. The mechanism(s) involved were unclear. In this study, we repeated similar approaches in of the same subjects pretreated for 3 days with cimetidine, an H 2 receptor antagonist. The pattern of exogenous histamine effects was now different in that local exogenous histamine (50 ug/ml) did not significantly alter ragweed‐induced mast cell alteration, histamine release, or the degree of eosinophil accumulation in skin challenge sites. These findings suggest that the observed exogenous histamine inhibitory effects may be mediated through the H 2 receptor.