Premium
Intranasal Immunotherapy with Polymerized Grass Pollen Allergens
Author(s) -
Schumacher M. J.,
Pain M. C. F.
Publication year - 1982
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1982.tb01906.x
Subject(s) - allergen , lolium perenne , nasal administration , medicine , hay fever , immunology , nasal provocation test , provocation test , immunogenicity , nasal lavage , placebo , immunoglobulin e , acoustic rhinometry , allergy , nasal cavity , antibody , surgery , pathology , biology , agronomy , alternative medicine , poaceae
The effect of immunotherapy by intranasal insulflation a of Lolium perenne allergens modified with glutaraldehyde (Glu‐Rye) was tested by a stratified placebo‐controlled trial in 16 adult subjects with hay fever. The purpose of this pilot study was to determine whether the treatment could reduce nasal sensitivity to allergen in provocation tests. Modification of the allergen was shown to include polymerization and reduced allergenicity, but retained immunogenicity. Nasal sensitivity to unmodified L. perenne allergens was measured by threshold‐type quantitative nasal challenge and posterior rhinometry for measurement of nasal airway resistance. In challenge tests after a 10‐week course of intranasal preseasonal treatment with Glu‐Rye, nasal sensitivity was reduced, but this effect was not maintained when testing was repeated 9 months after treatment. Post‐seasonal serum levels of IgE antibodies to L. perenne were also not significantly affected by the treatment.