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Double‐Blind Crossover Trial Comparing Systemic Chromone‐Carboxylic Acid with Placebo in Patients with Atopic Dermatitis
Author(s) -
Kavli Gunnar,
Larsen PoulØlholm
Publication year - 1981
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1981.tb01877.x
Subject(s) - medicine , chromone , double blind , crossover study , atopic dermatitis , placebo , dermatology , anesthesia , chemistry , alternative medicine , pathology , stereochemistry
35 adult patients with atopic dermatitis were included in a double‐blind crossover trial comparing chromone‐2‐carboxylic acid, FPL 57787 18 mg × 4, with placebo. Each treatment period lasted for 6 weeks with clinical assessment every 3 weeks, 28 patients completed 3 weeks of each period. Significant differences at the 5 % level in favour of FPL 57787 were seen in the group starting on placebo. 17 patients completed the study. After 6 weeks there were no significant differences. 10 patients experienced dyspeptic side‐effects. Further studies are warranted on clearly allergic sub‐groups of atopic dermatitis patients.