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Immune Thrombocytopenia Due to Antazoline (Antistina®)
Author(s) -
Nielsen J. Lanng,
Dahl R.,
KissmeyerNielsen F.
Publication year - 1981
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1981.tb01865.x
Subject(s) - complement fixation test , thrombocytopenic purpura , drug , medicine , antibody , platelet , immunology , pharmacology , serology
Antazoline (Antistina®)‐induced thrombocytopenic purpura occurring on three occasions in a 21‐year‐old woman is reported. After withdrawal of the drug she recovered promptly. In vitro investigation demonstrated the presence of an antibody in serum, which in association with antazoline caused complement fixation when added to test platelets. Also platelet agglutinins could be detected in the patient's serum when antazoline was added. The reactions were drug specific and they could still be demonstrated 9 months after the last exposure to the drug.