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Possible Role of Histamine in Rheumatoid Arthritis
Author(s) -
Permin H.,
Skov P. Stahl,
Norn S.,
Geisler A.,
Klysner R.,
Andersen V.,
Wiik A.,
Manthorpe R.,
Nielsen H.,
Petersen J.
Publication year - 1981
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1981.tb01852.x
Subject(s) - histamine , rheumatoid arthritis , medicine , immunology , gastroenterology
Basophilocytes from patients with rheumatoid arthritis (RA) responded to leukocyte nuclei from normal persons with histamine release; a similar histamine release induced by the nuclear components RNA and DNA has been demonstrated previously. A role of histamine in RA is also supported by the findings of clinical improvement during treatment with H 1 and H 2 antihistamines in six of 12 patients with RA in active phase, whereas four showed definite deterioration.