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Dialyzable Leukocyte Extract Stimulates cAMP in Tγ Lymphocytes
Author(s) -
Herlin Troels,
Jensen Jørgen R.,
ThestrupPedersen Kristian,
Zachariae Hugh
Publication year - 1981
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1981.tb01585.x
Subject(s) - receptor , t lymphocyte , stimulation , immunology , t cell , microbiology and biotechnology , rosette formation , biology , tcirg1 , t cell receptor , endocrinology , immune system , biochemistry
Dialyzable leukocyte extract (OLE) from human blood leukocytes gave a 3‐ to 8‐fold increase in the cAMP concentration after addition to purified lymphocytes. No significant change in cGMP was observed. When purified lymphocytes were separated into T cells and non‐T cells by an E‐AET rosette technique the cAMP response was most pronounced in T cells. When further separating T lymphocytes into T cells with Fc receptors for IgG and T cells with Fc receptors for IgM (Tγ and Tμ lymphocytes), the increase in cAMP following stimulation was specifically conferred to Tμ lymphocytes. Our findings may support the concept that DLE activates Tγ lymphocytes, leading to an increase in suppressor cell function.