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Impaired Monocyte Cyclic AMP Responses and Monocyte Cytotoxicity in Atopic Dermatitis
Author(s) -
Herlin Troels,
Kragballe Knud
Publication year - 1980
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1980.tb02017.x
Subject(s) - histamine , atopic dermatitis , antibody dependent cell mediated cytotoxicity , monocyte , medicine , cytotoxicity , immunology , cyclic adenosine monophosphate , endocrinology , allergen , allergy , antibody , chemistry , receptor , biochemistry , in vitro , monoclonal antibody
Purified monocytes from 21 patients with mild and severe atopic dermatitis (AD) were compared with 22 healthy controls with respect to antibody‐dependent cell‐mediated cytotoxicity (ADCC) and cyclic adenosine 3′,5′‐monophosphate (cAMP) responses to stimulatory agents. ADCC was depressed in both severe and mild atopic dermatitis. The patients showed decreased cAMP responses to isoproterenol and histamine, the decrement being more distinct in severe atopic dermatitis. Formation of cAMP was diminished with PGE, only in patients with severe AD. ADCC is inhibited by the agents that increase cAMP. In the severe dermatitis group reduced inhibition induced by isoproterenol, histamine, but not PGE 1 , was obtained. It is suggested that a general suppression of membrane activation may explain the reduced cAMP responses to various stimulatory agents and the impaired monocyte cytotoxicity.