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Inhalation of Racemic Epinephrine in Children with Asthma
Author(s) -
Kjellmas B.,
Tollig H.,
Wettrell G.
Publication year - 1980
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1980.tb01811.x
Subject(s) - salbutamol , inhalation , medicine , anesthesia , asthma , epinephrine , blood pressure , sore throat , heart rate , bronchodilator
In this study the effects of nebulized racemic epinephrine (Micronephrine) were investigated in children with asthma. The drug was inhaled by a compressor nebulizator with a plastic mask. In the first part of the study it is shown that nebulized Micronephrine has a dose‐dependent bronchodilatory effect. In the second part the effect is compared with that of nebulized salbutamol 10 children (7‐16 years of age) with bronchial asthma. The highest dose used in the dose‐response trials (=0.9 mg Micronephrine/kg body‐weight) was compared with 0.15 mg salbutamol/kg body‐weight, which is the dose commonly used in Sweden There was no significant difference between the drugs as regards increase of forced expiratory volume in 1 sec or duration of the increase. The was a small but significant increase in systolic blood pressure, measured 5 min after the inhalation of Micronephrine but no significant change in diastolic pressure of heart rate. Four children complained of temporary sore throat after the inhalation.