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Studies on Histamine Metabolism in Allergen‐Induced Asthma
Author(s) -
Löwhagen O.,
Granerus G.,
Wetterqvist H.
Publication year - 1980
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1980.tb01799.x
Subject(s) - histamine , excretion , provocation test , metabolite , allergen , urine , chemistry , endocrinology , asthma , medicine , allergy , pharmacology , immunology , pathology , alternative medicine
The excretion of histamine (Hi) and its metabolite methythistamine (MeHi)was determined in separated fractions of urine up to 12h alter standardized allergen provocations in 18 adult patients wild defined extrinsic bronchial asthma. The main histamine metabolite, methylimidazoleacetic acid (MelmAA), was measured in six of the patients. After positive provocations (decrease in FEV 1 > 20%) the excretion of Hi was significantly increased during 3h and that of MeHi during 4h after challenge. Negative provocations (decrease in FEV 1 <20%) were not followed by any changes in the excretion of Hi and MeHi. MelmAA excretion increased in five out of six patients after positive provocation. It was calculated that the increased excretion of Hi and its metabolites after a positive provocation corresponded to a release of about 1 mg histamine in the body or about 1 μg/g lung tissue if all histamine was liberated in the lung. Pretreatment with two anti‐allergic drugs, disodium cromoglycate and ICI 74.917, giving significant allergen protection, resulted in a smaller increase of the excretion of both Hi and MeHi, indicating an inhibition of histamine release in vivo.