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Effect of Topical Indomethacin on Allergen‐Induced Dual Skin Reactions
Author(s) -
Dorsch W.,
Baur X.
Publication year - 1980
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1980.tb01797.x
Subject(s) - medicine , allergen , skin reaction , dual (grammatical number) , dermatology , allergy , immunology , art , literature
Twelve asthmatics with dual bronchial and skin reactions after allergen challenge received topical treatment with a 5%‐indomethacin cream half an hour before and up to 7h after intradermal allergen and histamine injections. The erythema during the first 20 min of the wheal and flare reaction (WFR) was not affected, neither were the diameters of wheals and flares. 40 to 60 min after injection we observed a marked reduction of the erythema in histamine‐and allergen‐tested skin areas of 10 Patients. This effect lasted up to the 5th h alter injection of high allergen doses. During the hilly developed late cutaneous reactions (LCR) no effect 0f indomethacin on the erythema was observed, the edema of LCR was only insignificantly reduced. These results suggest that the erythema in LCR between the 1st and 4th is caused, at least in part, by local formation of prostaglandins.