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Cutaneous Responses to Allergen after Local Pretreatment with Beta‐Adrenoceptor Stimulating and Blocking Agents
Author(s) -
Grönneberg Reidar,
Strandberg Kjell,
Hägermark ÖSten
Publication year - 1980
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1980.tb01786.x
Subject(s) - terbutaline , propranolol , microgram , pharmacology , beta (programming language) , allergen , fenoterol , chemistry , histamine , allergy , medicine , endocrinology , in vitro , immunology , asthma , biochemistry , computer science , programming language
β‐Adrenoceptor stimulating agents possess anti‐allergic effects in vitro and in vivo. To study the mechanism of action further we compared in 10 atopic subjects the effects on allergen‐induced cutaneous reactions of intradermally (i.d.) injected prenalterol (1–10 μg) terbutaline (2.5‐250 ng) and KWD 2131 (100ng‐2.5 μg), i.e. compounds with preferential actions on β 1 ‐, β 2 , ‐adrenoceptors and on β‐adrenoceptors not fitting this classification. All injections were given according to a double‐blind design. Terbutaline and KWD 2131 produced a dose‐dependent inhibition of the skin reactions induced by injecting horse dander allergen 5 min later. Terbutaline was about 20 times as potent as KWD 2131 whereas prenalterol was inactive. Propranolol fully blocked the anti‐allergic effect produced by terbutaline. The results suggest that the cutaneous anti‐allergic effect of β‐adrenoceptor‐stimulating drugs is mediated via activation of β 2 ‐adrenoceptors, possibly on the mast cell, resulting in inhibition of mediator release.