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Standardized Allergen Provocation Test
Author(s) -
Loẅhagen O.,
Lindholm N. B.
Publication year - 1980
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1980.tb01777.x
Subject(s) - provocation test , medicine , allergen , asthma , allergy , methacholine , immunology , respiratory disease , pathology , alternative medicine , lung
Standardized bronchial allergen provocation with the same individual allergen dose was performed 3–9 times in 20 symptomless adult asthmatic patients at intervals of 1 week or more during 1/222 months in order to study variations in bronchial response. The immediate type reaction was recorded by monitoring FEV 1 , FVC, PEFR and MEF 50% for 30–40 min after provocation. FEV 1 was highly significantly correlated to the other variables. The coefficient of variation corresponding to maximum decrease in FEV, was 23%. All provocations were followed by a bronchial reaction within clinically acceptable limits. There was no indication of hypo‐ or hypersensitization. It is concluded that although many different factors influence the bronchial response, careful standardization of the provocation procedure leads to a moderate variation in bronchia! response, making the allergen provocation test suitable for pathophysiological studies and clinical evaluation of anti–asthmatic drugs.