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Effect of Bordetella pertussis Vaccination in Mice and the Isolated Tracheal Response to Isoprenaline
Author(s) -
Bartell Thad E.,
Busse William W.
Publication year - 1980
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1980.tb01769.x
Subject(s) - bordetella pertussis , isoprenaline , carbachol , pertussis vaccine , medicine , pertussis toxin , immunology , anesthesia , endocrinology , biology , immune system , immunization , stimulation , g protein , receptor , bacteria , genetics
The administration of Bordetella pertussis vaccine to mice has been associated with the development of an impaired beta‐adrenoceptor responsiveness and in many respects has resembled human asthma. Trachea ( n =12) were isolated from Swiss‐Webster mice 5 days following the intraperitoneal administration of 2 × 10 9 B. pertussis organisms. The tracheal smooth muscle response to carbachol was measured and compared with that found in trachea from unvaccinated mice ( n =15). The contractile response was similar in both groups. The tracheal smooth muscle relaxant effects of isoproterenol were measured in these two groups. The EC 50 value for isoprenaline (6.5 × 10 –7 M) in trachea from B. pertussis treated mice was significantly ( P 0.05) greater than that noted in the control animals (2.3 × 10 −7 M). These studies demonstrated that in tracheal smooth muscle isolated from B. pertussis vaccinated mice, the relaxant effects of isoprenaline are impaired.