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Antigen‐Induced Bronchial Anaphylaxis in Actively Sensitized Guinea‐Pigs Pattern of Response in Relation to Immunization Regimen
Author(s) -
Andersson Per
Publication year - 1980
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1980.tb01718.x
Subject(s) - ovalbumin , immunology , immunoglobulin e , anaphylaxis , antigen , guinea pig , medicine , bronchoconstriction , antibody , alum , bronchospasm , allergy , immunization , asthma , chemistry , organic chemistry
This work studies the temporal development of the acute anaphylactic bronchoconstriction in guinea‐pigs sensitized to ovalbtiin by different regimens, including IgE‐antibody promoting ones. The results show that guinea‐pigs sensitized with low amounts (1‐10μg) of ovalbumin together with alum produce the most pronounced bronchospasm when challenged with an intravenous injection of a low dose of antigen. Examination of the antibody classes by PCA technique shows that guinea‐pigs sensitized with small amounts of antigen together with alum produce IgE and IgG 1 antibodies. However, in sera from animals immunized with large amounts of antigen, only IgG 1 antibodies could be detected.