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Metabolism of 14 C‐Histamine Given Intrabronchially to Asthmatic Patients
Author(s) -
Granerus G.,
Bergmark J.,
Löwhagen O.,
Thiringer G.
Publication year - 1980
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1980.tb01714.x
Subject(s) - histamine , excretion , endocrinology , chemistry , medicine , diuresis , metabolism , urine , kidney
14 C‐histamine was administered intrabronchially to asthmatic patients and controls. The urinary excretion of total radioactivity, 14 C‐histamine and its radioactive metabolites was measured. It was found that the excretion of total radioactivity was complete within 24 h. The excretion rate was equal to that observed after intravenous injection of 14 C‐histamine, indicating a rapid penetration of the bronchial mucosa. However, the diuresis seemed to be of importance for the excretion rate. Histamine inactivation by methylation was more pronounced after intrabronchial than after intravenotis administration.