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Cyclic AMP in Hypersensitivity Reactions
Author(s) -
Vervloet D.,
Anfosso F.,
Vellieux P.,
Charpin J.
Publication year - 1979
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1979.tb02012.x
Subject(s) - histamine , intracellular , agonist , chemistry , endocrinology , medicine , cytotoxic t cell , inhibitory postsynaptic potential , biology , biochemistry , receptor , in vitro
Phytohemagglutinin (PHA) was capable of inducing non‐cytotoxic histamine release from human leucocytes. In the presence of deuterium oxide (D 2 O), PHA caused significantly greater histamine release. Dibutyryl cyclic AMP id‐cAMP) could enhance the histamine release in the presence of D 2 O although it was an inhibitor of the release if used alone. However, a β agonist, isoproterenol, which increases intracellular level of cAMP was inhibitory with or without D 2 O. These data ask the question about dual effect of cAMP and suggest the possibility of different pools of cAMP in the target cells.