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Antibody‐Dependent Monocyte‐Mediated Cytotoxidty in Severe Atopic Dermatitis
Author(s) -
Kragballe Knud
Publication year - 1979
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1979.tb01998.x
Subject(s) - atopic dermatitis , monocyte , immunology , medicine , cytotoxicity , antibody , disease , biology , pathology , in vitro , biochemistry
Antibody‐dependent monocyte‐mediated cytotoxicity was studied in nine patients with severe atopic dermatitis during flares of their disease. In all cases the cytotoxicity was depressed. The disturbed function may contribute to the severe cutaneous infections seen in these patients. It remains to be seen if these patients have an intrinsic monocyte defect or if an inhibiting factor only is operating during active disease states.