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A Double Blind Controlled Trial of N‐(3′, 4′‐Dimethoxycinnamoyl) Anthranilic Acid on Children with Bronchial Asthma
Author(s) -
Shioda
Publication year - 1979
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1979.tb01701.x
Subject(s) - asthma , double blind , anthranilic acid , medicine , pediatrics , placebo , alternative medicine , chemistry , pathology , organic chemistry
A double blind controlled trial of N‐(3′, 4′‐dimethoxycinnamoyl) anchranilic acid (N‐5′) was carried out for treating children with bronchial asthma to determine its efficacy and safety. The results showed that the drug was significantly more effective in the N 10 and N 5 groups than in the N 0 group. Adverse reactions appeared only in one patient in the N 10 group who complained of slight anorexia while another patient in the N 0 group reported moderate diarrhoea. Moreover there was no indication of abnormality in further laboratory investigations. It can be therefore concluded that this drug is useful for the treatment of children with bronchial asthma.