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Aluminium Phosphate but Not Calcium Phosphate Stimulates the Specific IgE Response in Guinea Pigs to Tetanus Toxoid
Author(s) -
Vassilev Tchavdar L.
Publication year - 1978
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1978.tb01527.x
Subject(s) - toxoid , tetanus , calcium , phosphate , immunology , immunoglobulin e , chemistry , medicine , biology , biochemistry , antibody , vaccination
The ability of aluminium phosphate and calcium phosphate to stimulate the synthesis of tetanus toxoid‐specific anaphilactic and antitoxic antibodies is compared. The observed differences in the kinetics of IgG 1a , IgG 3b , and antitoxines are quantitative–titres alter application of aluminium phosphate are higher. Booster immunization with aluminium but not calcium phosphate‐adsorbed toxoid Leads to a prolonged synthesis of specific IgE. It is hypothesized that the regular application of aluminium compound‐containing vaccines on the entire population could be one of the factors leading 10 the observed increase of allergic diseases.