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HYPOTHESIS‐DETERMINANT FACTORS IN THE MANIFESTATIONS OF ATOPIC DISEASE
Author(s) -
BRASHER GEORGE W.
Publication year - 1977
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1977.tb01352.x
Subject(s) - george (robot) , white (mutation) , citation , medicine , classics , library science , gerontology , history , art history , computer science , biochemistry , chemistry , gene
It is postulated that both the initiation and the perpetuation of atopic disease occur as a result of a complex interaction of a genetically determined IgE response, increased permeability of the gastrointestinal and respiratory tracts, and an inherent metabolic instability that may be either localized or generalized. These three factors vary as a function of age and serve to explain the complicated natural history of allergic manifestations in atopic persons.