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CYCLIC AMP AND ALLERGIC HISTAMINE RELEASE. INFLUENCE OF METHYLXANTHINES ON RAT MAST CELLS
Author(s) -
NORN S.,
GEISLER A.,
SKOV P. STAHL,
KLYSNER R.
Publication year - 1977
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1977.tb01348.x
Subject(s) - clinical pharmacology , histamine , medicine , library science , pharmacology , computer science
Both isobutylmethylxanthine and theophylline increased the level of cyclic AMP in rat mast cells. Theophylline reduced the allergic histamine release, whereas isobutylmethylxanthine caused a pronounced potentiation of the histamine release. This indicates that the hypothesis of an inverse relationship between the level of cyclic AMP in mast cells and histamine release is inadequate.