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POTENTIATION OF CUTANEOUS REACTIVITY AND BLOOD LEUCOCYTE HISTAMINE RELEASE BY DEUTERIUM OXIDE IN HUMAN BEINGS
Author(s) -
VERVLOET D.,
VELLIEUX P.,
CHARPIN J.
Publication year - 1976
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1976.tb01696.x
Subject(s) - histamine , long term potentiation , reactivity (psychology) , pharmacology , chemistry , medicine , immunology , pathology , alternative medicine , receptor
Deuterium oxide (D2O) is known to potentiate non-cytotoxic histamine release in vitro. It has been shown (5) that D2O could also potentiate in vivo immediate-type hypersensitivity in dogs and monkeys. Present studies demonstrate potentiation in vivo by D2O of the cutaneous reactivity in 48/80, PHA and Dermatophagoides cutaneous reactions in human beings. PHA histamine release from human leucocytes is also potentiated by D2O in vitro.

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