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MAST CELL SENSITIZING ANTIBODY (MCSAb) RESPONSE IN EXPERIMENTAL CANDIDIASIS: CHROMATOGRAPHIC STUDIES
Author(s) -
VARDI N.,
SEGAL E.,
SCHWARTZ J.,
EYLAN E.
Publication year - 1975
Publication title -
allergy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1975.tb01335.x
Subject(s) - heterologous , antibody , mast cell , candida albicans , immunogenicity , immunology , globulin , microbiology and biotechnology , antigen , adjuvant , immunoglobulin e , biology , chemistry , biochemistry , gene
A single dose of the yeast-like fungus Candida albicans (CA), mixed with Complete Freund's Adjuvant (CFA), and inoculated into guinea-pig foot-pads, provoked the productions of homologous mast cell sensitizing antibodies (MCSAb) present in the psiI-globulin fraction only, and of agglutinins localized in the same fraction. Heterologous MCSAb and skin-sensitizing antibodies detectable by passive cutaneous anaphylaxis (PCA) were constantly absent. These facts are in contradiction to results of previous experiments performed with other antigens; which after similar inoculation elicited production of heterologous MCSAb attaching themselves on rat mast cells (MC) and present in the psi2 fast moving globulin, homologous MCSAb localized in the psiI-globulin and in the psi2 fast moving globulin, and PCA antibodies. The immunogenicity of CA is discussed.