Premium
TOPICAL TREATMENT OF DERMATITIS HERPETIFORMIS WITH BETAMETHASONE‐17‐VALERATE AND FLUOCINOLONE ACETONIDE
Author(s) -
BJÖRNBERG ALF,
HELLGREN LARS
Publication year - 1966
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1966.tb03165.x
Subject(s) - fluocinolone acetonide , medicine , dermatology , dermatitis herpetiformis , atopic dermatitis , pityriasis rubra pilaris , psoriasis , disease
The treatment of dermatitis herpetiformis with sulfapyridine and sulfones has disadvantages. Some patients become resistent to the treatment and high doses must often be used. These may give toxic reactions, i. e. haemolytic anemia of the sulfones. The intention of this study was therefore to find an alternative to the used treatment. A topical treatment might be suitable especially in the common localized types of the disease. Hydrocortisone and earlier steroid preparations generally had no effect on the dermatitis herpetiformis, either used topically or systemically with moderate doses. However fluocinolone acetonide under occlusive bandage was shown by us to have a benefical effect on the disease {Bjornberg &. Hellgren 1964). Referring to our previous experiences with betamethasone17-vaIerate in different inflammatory dermatosis, we presumed that this new potent steroid might have a beneficial effect on dermatitis herpetiformis and a double blind investigation was therefore performed in comparison with fluocinolone acetonide.