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N ‐(2‐methyl‐6‐benzoxazolyl)‐ N ′‐1,5‐naphthyridin‐4‐yl urea ( SB 334867), a hypocretin receptor‐1 antagonist, preferentially prevents ethanol seeking: comparison with natural reward seeking
Author(s) -
MartinFardon Rémi,
Weiss Friedbert
Publication year - 2014
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1111/j.1369-1600.2012.00480.x
Subject(s) - antagonist , saccharin , ethanol , orexin , chemistry , pharmacology , receptor , endocrinology , neuropeptide , medicine , biochemistry
Orexins/hypocretins ( O rx/ H crt) are hypothalamic peptides that regulate a wide range of physiological processes and have been shown to be recruited by drugs of abuse. This study was designed to test the effect of the specific O rx/ H crt receptor‐1 ( H crt‐r1) antagonist, N ‐(2‐methyl‐6‐benzoxazolyl)‐ N ′‐1,5‐naphthyridin‐4‐yl urea ( SB 334867), on reinstatement elicited by ethanol ( EtOH )‐associated stimuli versus stimuli associated with a conventional reinforcer [i.e. S uper S ac, consisting of 3% glucose and 0.125% saccharin (w/v)]. SB 334867 (1–10 mg/kg, i.p.) dose‐dependently reduced reinstatement induced by the EtOH ‐ but not S uper S ac‐associated stimuli. These findings support a differential role of H crt‐r1 in mediating EtOH seeking versus natural reward seeking.