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Optogenetic inhibition of cocaine seeking in rats
Author(s) -
Stefanik Michael T.,
Moussawi Khaled,
Kupchik Yonatan M.,
Smith Kyle C.,
Miller Rachel L.,
Huff Mary L.,
Deisseroth Karl,
Kalivas Peter W.,
LaLumiere Ryan T.
Publication year - 2013
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1111/j.1369-1600.2012.00479.x
Subject(s) - optogenetics , nucleus accumbens , halorhodopsin , extinction (optical mineralogy) , neuroscience , self administration , infralimbic cortex , inhibitory postsynaptic potential , pharmacology , psychology , medicine , chemistry , prefrontal cortex , central nervous system , biochemistry , mineralogy , cognition , bacteriorhodopsin , membrane
Inhibitory optogenetics was used to examine the roles of the prelimbic cortex ( PL ), the nucleus accumbens core ( NAcore ) and the PL projections to the NAcore in the reinstatement of cocaine seeking. Rats were microinjected into the PL or NAcore with an adeno‐associated virus containing halorhodopsin or archaerhodopsin. After 12 days of cocaine self‐administration, followed by extinction training, animals underwent reinstatement testing along with the presence/absence of optically induced inhibition via laser light. Bilateral optical inhibition of the PL , NAcore or the PL fibers in the NAcore inhibited the reinstatement of cocaine seeking.