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Association between a polymorphism in the promoter of a glutamate receptor subunit gene ( GRIN2A ) and alcoholism
Author(s) -
Domart MarieCharlotte,
Benyamina Amine,
Lemoine Antoinette,
Bourgain Catherine,
Blecha Lisa,
Debuire Brigitte,
Reynaud Michel,
Saffroy Raphaël
Publication year - 2012
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1111/j.1369-1600.2011.00321.x
Subject(s) - alcohol dependence , allele , odds ratio , polymorphism (computer science) , genotype , alcohol , medicine , genetics , gene , biology , biochemistry
A variable (GT) n repeat in the 5′‐regulatory region of N ‐methyl‐D‐aspartate GRIN2A subtype has recently been identified and associated with psychiatric disorders. In this study, we examined the association of this polymorphism with alcohol dependence. Subject–control analysis included 206 alcohol‐dependent and 168 control subjects. Average observed repeat numbers and genotype distributions were significantly different ( P ‐value = 0.001) in alcohol‐dependent subjects versus control subjects. Short alleles were significantly less frequent among alcohol‐dependent subjects (odds ratio = 0.58, P ‐value = 7 × 10 −4 ). These results could be replicated in an independent sample of 116 alcohol‐dependent subjects. For the first time, a significant association was identified between this polymorphism and alcoholism.