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No association of candidate genes with cannabis use in a large sample of Australian twin families
Author(s) -
Verweij Karin J. H.,
Zietsch Brendan P.,
Liu Jimmy Z.,
Medland Sarah E.,
Lynskey Michael T.,
Madden Pamela A. F.,
Agrawal Arpana,
Montgomery Grant W.,
Heath Andrew C.,
Martin Nicholas G.
Publication year - 2012
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1111/j.1369-1600.2011.00320.x
Subject(s) - cannabis , candidate gene , association (psychology) , twin study , genetic association , replication (statistics) , psychology , gene , genetics , biology , psychiatry , single nucleotide polymorphism , genotype , heritability , virology , psychotherapist
While there is solid evidence that cannabis use is heritable, attempts to identify genetic influences at the molecular level have yielded mixed results. Here, a large twin family sample ( n = 7452) was used to test for association between 10 previously reported candidate genes and lifetime frequency of cannabis use using a gene‐based association test. None of the candidate genes reached even nominal significance ( P < 0.05). The lack of replication may point to our limited understanding of the neurobiology of cannabis involvement and also to potential publication bias and false‐positive findings in previous studies.