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Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents
Author(s) -
Desrivières Sylvane,
Lourdusamy Anbarasu,
Müller Christian,
Ducci Francesca,
Wong Cybele P.,
Kaakinen Marika,
Pouta Anneli,
Hartikainen AnnaLiisa,
Isohanni Matti,
Charoen Pimphen,
Peltonen Leena,
Freimer Nelson,
Elliott Paul,
Jarvelin MarjoRiitta,
Schumann Gunter
Publication year - 2011
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1111/j.1369-1600.2010.00239.x
Subject(s) - glucocorticoid receptor , alcohol dependence , addiction , glucocorticoid , alcohol , odds ratio , alcohol abuse , polymorphism (computer science) , age of onset , psychology , odds , medicine , psychiatry , clinical psychology , genetics , gene , biology , allele , logistic regression , disease , biochemistry
Onset of alcohol use at an early age increases the risk for later alcohol dependence. We investigated the role of the glucocorticoid receptor (GR) gene ( NR3C1 ) in onset of alcohol use and abuse in 14‐year‐old adolescents ( n = 4534). Several NR3C1 polymorphisms were associated with onset of alcohol drinking or drunkenness at this age. Strongest associations were observed in females, with one marker (rs244465) remaining significant after correction for multiple testing ( P adj = 0.0067; odds ratio = 1.7, for drunkenness). Our data provide the first evidence that GR modulates initiation of alcohol abuse and reveal a polymorphism that might contribute to susceptibility to addiction.