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REVIEW: Behavioral evidence for the significance of serotoninergic (5‐HT) receptors in cocaine addiction
Author(s) -
Filip Małgorzata,
Alenitalia,
Bader Michael,
Przegaliński Edmund
Publication year - 2010
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1111/j.1369-1600.2010.00214.x
Subject(s) - serotonergic , addiction , serotonin , psychology , 5 ht receptor , sensitization , receptor , conditioned place preference , neuroscience , pharmacology , psychiatry , medicine
Cocaine addiction has somatic, psychological, psychiatric, socio‐economic and legal implications in the developed world. Presently, there is no medication approved for the treatment of cocaine addiction. In recent years, data from the literature (pre‐clinical studies and clinical trials) have provided several lines of evidence that serotonin (5‐HT) and 5‐HT receptors play a modulatory role in the mechanisms of action of cocaine. Here we review the contribution of 5‐HT receptor subtypes to cocaine sensitization, discrimination, conditioned place preference, self‐administration, reinstatement of seeking behavior and withdrawal symptoms in laboratory animals. Additionally, the consequences of chronic cocaine exposure on particular 5‐HT receptor‐assigned functions in pre‐clinical studies are presented.