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BRIEF REPORT: Single exposure to cocaine or ecstasy induces DNA damage in brain and other organs of mice
Author(s) -
Alvarenga Tathiana A.,
Andersen Monica L.,
Ribeiro Daniel A.,
Araujo Paula,
Hirotsu Camila,
Costa José L.,
Battisti Murilo C.,
Tufik Sergio
Publication year - 2010
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1111/j.1369-1600.2009.00179.x
Subject(s) - ecstasy , neuroscience , dna damage , pharmacology , mdma , psychology , toxicology , medicine , biology , dna , genetics , psychiatry
ABSTRACT We evaluated the overall genetic damage induced by different doses of cocaine and MDMA (3,4‐Methylenedioxymethamphetamine) in several organs. One hour after intraperitoneal drug administration, mice were euthanized; peripheral blood, liver and brain were collected, and the cellular suspensions were used for the single cell gel (comet) assay. We determined that all doses of cocaine and MDMA tested were able to induce DNA damage in blood cells. Extensive genotoxic damage was induced by cocaine or MDMA at the highest doses used in liver cells. Brain cells were affected by all doses administrated. These findings demonstrate that cocaine and MDMA are potent genotoxins.