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PRECLINICAL STUDY: Pentylenetetrazole‐induced status epilepticus following training does not impair expression of morphine‐induced conditioned place preference
Author(s) -
Zhang Jie,
Tan Hua,
Niu Hai C.,
Wang Jian H.,
Tang Xiang D.,
Sanford Larry D.,
Ma YuanYe
Publication year - 2009
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1111/j.1369-1600.2008.00122.x
Subject(s) - morphine , conditioned place preference , morris water navigation task , psychology , pharmacology , neuroscience , anesthesia , medicine , hippocampus
Learning and memory play an important role in morphine addiction. Status epilepticus (SE) can impair the spatial and emotional learning and memory. However, little is known about the effects of SE on morphine‐induced conditioned place preference (CPP). The present study was designed to investigate the effects of SE on morphine CPP, with food CPP being used as a control. The effects of SE on spatial memory in the Morris water maze (MWM) and Y‐maze were investigated. SE was induced in adult mice using intraperitoneal injection of pentylenetetrazole; control mice received saline. The data indicated that SE had no effects on the formation of morphine CPP; however, the formation of food CPP was blocked by SE. Meanwhile, spatial memory assayed in the MWM and Y‐maze was impaired by SE. In addition, the data demonstrated that SE did not cause a lasting disturbance of motor activity nor a change in the mice's appetite. These results suggested that although SE had no effects on morphine CPP, there was impaired food CPP and spatial memory in both the MWM and the Y‐maze. The mechanisms underlying memory process of morphine CPP may be different from other types of memory.