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PRECLINICAL STUDY: Effects of chronic stress on nicotine‐induced locomotor activity and corticosterone release in adult and adolescent rats
Author(s) -
Cruz Fábio C.,
DeLucia Roberto,
Planeta Cleopatra S.
Publication year - 2008
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1111/j.1369-1600.2007.00080.x
Subject(s) - corticosterone , nicotine , endocrinology , medicine , saline , radioimmunoassay , locomotor activity , adult male , chronic stress , hormone
We examined nicotine‐induced locomotion and increase in corticosterone plasma levels in adolescent and adult animals exposed to chronic restraint stress. Adolescent [postnatal day (P) 28–37] and adult (P60–67) rats were restrained for 2 hours once daily for 7 days. Three days after the last exposure to stress, the animals were challenged with saline or nicotine (0.4 mg/kg subcutaneously). Nicotine‐induced locomotion was recorded in an activity cage. Trunk blood samples were collected in a subset of adolescent and adult rats and plasma corticosterone levels were determined by radioimmunoassay. Exposure to stress did not affect the nicotine‐induced locomotor‐ or corticosterone‐activating effects in both ages.